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Dr Sanish Sathyan

Assistant Professor

  09895069758

  sanishsathyan@kannuruniv.ac.in

Qualifications :   Ph.D. Biotechnology

Aging biology; longevity; frailty; dementia; human genetics; proteomics of aging, and age-associated disorders; aging clock and phenotype prediction.

Education

  • Ph.D., Biotechnology (2009-2015): Kerala University - Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram.
  • M.Sc., Microbiology (2006-2008): Kannur University, Kerala.
  • B.Sc., Microbiology (2003-2006): S. N. College, Kannur University, Kerala.

Post-Doctoral Experience

  • 2025-2025 Research Assistant Professor, Stony Brook University, New York
  • 2022-2025 Research Assistant Professor, Albert Einstein College of Medicine, New York
  • 2016-2021 Post doctoral Research fellow, Albert Einstein College of Medicine, New York.

Awards and Honors:

  • Recipient of the Dr. M. R. Das Career Award for best overall Ph.D. performance from RGCB, Trivandrum.
  • Junior and Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), India (2009-2014).
  • Awarded 2nd rank at the university level for his M.Sc. in Microbiology from Kannur University.

Professional Activities:

  • Associate Editor: Journal of Gerontology Medical Science (JGMS).
  • Editorial Board Member: Neurodegenerative Diseases journal, Genetics section.

Research & Projects

The research focuses on the biology of aging, longevity, frailty, dementia. This work involves using multi-omics approaches to understand the genetic and molecular underpinnings of health and disease in older adults. Previous postdoctoral work at the Albert Einstein College of Medicine centered on the biology of aging at both proteomic and genetic levels. Key projects included establishing a proteomic aging clock (PAC) to predict mortality and health outcomes, identifying proteomic changes associated with frailty and aging, and collaborating on landmark studies published in Nature and Nature Medicine to establish organ-specific aging clocks and map proteomic changes across the human lifespan.I have been part of multiple NIH funded projects.

Publications

  1. Sathyan, S., Liu, F., Tanaka, T., Ferrucci, L., Ayers, E., Windham, B.G., Gao, T., Weiss, E.F., Candia, J., Coresh, J., & Barzilai, N. (2025). A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults. Aging Cell, e70144. (Corresponding Author)
  2. Gomez, G.T., Sathyan, S., Chen, J., Fornage, M., Schlosser, P., Peng, Z., Cordon, J., Palta, P., Sullivan, K.J., Tin, A., & Windham, B.G. (2025). Plasma proteomic characterization of motoric cognitive risk and mild cognitive impairment. Alzheimer's & Dementia, 21(2), e14429.
  3. Verghese, J., Cotton, K., Sathyan, S., Ayers, E., Mahoney, J.R., De Sanctis, P., & Jayakody, O. (2025). Super movers: Epidemiology and biology of a novel exceptional aging phenotype. The Journals of Gerontology: Series A (Biological Sciences & Medical Sciences), glaf107.
  4. Sindura, K.P., Sebastian, M., Davis, P., Srinivas, L., Sathyan, S., Anaswara, A., & Banerjee, M. (2025). Proinflammatory phenotype can be critical in defining and modulating the genetic risk of non-syndromic hearing loss. Human Immunology, 86(5), 111582.
  5. Mohamed, S.C., Beevi, R., Banerjee, M., Sathyan, S., Nayar, B.R., & Janam, P. (2025). Association of Gene Polymorphism of Matrix Metalloproteinase-9 with Chronic Periodontitis: A Cross-Sectional Survey in a South Indian Population. Cureus, 17(9).
  6. Cotton, K., Sathyan, S., Jacob, S., Shaji, K.S., Ayers, E., Adhikari, D., Sigamani, A., Pradeep Kumar, V.G., & Verghese, J. (2025). Translation and validation of the Malayalam version of the Subjective Happiness Scale. Social Indicators Research, 176(1), 245–255.
  7. Cotton, K., Sivaraman, S.K., Sathyan, S., Ayers, E., Adhikari, D., Ceïde, M.E., Sigamani, A., Kumar, P., & Verghese, J. (2024). Validation of a Malayalam Version of the Apathy Evaluation Scale. Indian Journal of Psychological Medicine, 02537176241276749.
  8. Jabalameli, M.R., Lin, J.R., Zhang, Q., Wang, Z., Mitra, J., Nguyen, N., Gao, T., Khusidman, M., Sathyan, S., Atzmon, G., & Milman, S. (2024). Polygenic prediction of human longevity on the supposition of pervasive pleiotropy. Scientific Reports, 14(1), 19981.
  9. Sathyan, S., Milman, S., Ayers, E., Gao, T., Verghese, J., & Barzilai, N. (2024). Plasma proteomic profile of abdominal obesity in older adults. Obesity.
  10. Hamilton Oh, H., Rutledge, J., Nachun, D., ... Sathyan, S., ... Wyss-Coray, T. (2023). Organ aging signatures in the plasma proteome track health and disease. Nature, 624(7990), 164–172.
  11. Sathyan, S., Ayers, E., Adhikari, D., Gao, T., Milman, S., Barzilai, N., & Verghese, J. (2023). Biological age acceleration and motoric cognitive risk syndrome. Annals of Neurology.
  12. Sathyan, S., Ayers, E., Blumen, H., Adhikari, D., Stimmel, M., Abdulsalam, K., Noone, M., George, R.K., Ceide, M., Ambrose, A.F., Narayanan, P., Wang, C., Sureshbabu, S., Shaji, K.S., Sigamani, A., Mathuranath, P.S., Pradeep, V.G., & Verghese, J. (2023). Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study. JMIR Research Protocols, 49933.
  13. Milman, S., Lerman, B., Ayers, E., Zhang, Z., Sathyan, S., Levine, M., Ye, K., Gao, T., Higgins-Chen, A., Barzilai, N., & Verghese, J. (2023). Frailty Resilience Score: A novel measure of frailty resilience associated with protection from frailty and survival. Journals of Gerontology: Series A, glad138.
  14. Sood, A., Cherian, L.M., Heera, R., Sathyan, S., & Banerjee, M. (2022). Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study. Journal of Oral Biology and Craniofacial Research, 12(2), 258–262.
  15. Verghese, J., Ayers, E., Sathyan, S., Lipton, R.B., Milman, S., Barzilai, N., & Wang, C. (2021). Trajectories of frailty in aging: Prospective cohort study. PLOS ONE, 16(7), e0253976.
  16. Sathyan, S., Ayers, E., Gao, T., Weiss, E.F., Milman, S., Verghese, J., & Barzilai, N. (2020). Plasma proteomic profile of age, healthspan, and all‐cause mortality in older adults. Aging Cell, e13250.
  17. Sathyan, S., Ayers, E., Gao, T., Milman, S., Barzilai, N., & Verghese, J. (2020). Plasma proteomic profile of frailty. Aging Cell, 19(9), e13193.
  18. Shafeeque, C.M., Sathyan, S., Saradalekshmi, K.R., Premkumar, S., Allapatt, J.P., & Banerjee, M. (2020). Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients. Epigenomics, 12(10), 859–871.
  19. Sathyan, S., & Verghese, J. (2020). Genetics of frailty: A longevity perspective. Translational Research, 221, 83–96.
  20. Lehallier, B., Gate, D., Schaum, N., ... Sathyan, S., ... Wyss-Coray, T. (2019). Undulating changes in human plasma proteome profiles across the lifespan. Nature Medicine, 25, 1843–1850.
  21. Sathyan, S., Ayers, E., Gao, T., Milman, S., Barzilai, N., Rockwood, K., & Verghese, J. (2019). Frailty and risk of incident motoric cognitive risk syndrome. Journal of Alzheimer’s Disease, 71(S1), S85–S93.
  22. Sathyan, S., Wang, T., Ayers, E., & Verghese, J. (2019). Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study. Neurology, 92, e1427–e1434.
  23. Aloka, D., Padmakumar, S., Sathyan, S., Sebastian, M., & Banerjee, M. (2019). Association of matrix metalloproteinase 2 and 9 gene polymorphism in aggressive and nonaggressive odontogenic lesions: A pilot study. Journal of Oral and Maxillofacial Pathology, 23, 158.
  24. Sathyan, S., Barzilai, N., Atzmon, G., Milman, S., Ayers, E., & Verghese, J. (2018). Genetic insights into frailty: Association of 9p21-23 locus with frailty. Frontiers in Medicine, 5, 105.
  25. Sathyan, S., Barzilai, N., Atzmon, G., Milman, S., Ayers, E., & Verghese, J. (2017). Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population. Neurobiology of Aging, 58, 238.e1.
  26. Chauhan, I., Sugirtharaj, G., Sathyan, S., Beena, V.T., & Banerjee, M. (2016). Evaluation of salivary DNA obtained from dental prosthesis and its applicability in forensic investigations. Journal of Forensic and Legal Medicine, 42, 100–105.
  27. Sathyan, S., Koshy, L.V., Srinivas, L., Easwer, H., Premkumar, S., Nair, S., Bhattacharya, R., Alapatt, J.P., & Banerjee, M. (2015). Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors. Journal of Neuroinflammation, 12, 135.
  28. Panda, S., Beena, V., Sivakumar, R., Choudhary, K., Nalinakumari, K., Sathyan, S., & Banerjee, M. (2015). Microsatellite instability in D2S123 flanking the hMSH2 gene in oral squamous cell carcinoma in South India. Clinical Cancer Investigation Journal, 4, 22.
  29. Choudhary, K., Sathyan, S., Beena, V., Panda, S., Sivakumar, R., Ahuja, A., & Banerjee, M. (2015). Polymorphic variants of mismatch repair gene MutS homologue-2 influence oral squamous cell carcinoma in a South Indian population. Clinical Cancer Investigation Journal, 4, 170.
  30. Sathyan, S., Koshy, L.V., Balan, S., Easwer, H., Premkumar, S., Nair, S., Bhattacharya, R., Alapatt, J.P., & Banerjee, M. (2014). Association of Versican (VCAN) gene polymorphisms rs251124 and rs2287926 (G428D) with intracranial aneurysm. Meta Gene, 2, 651–660.
  31. Saradalekshmi, K.R., Neetha, N.V., Sathyan, S., Nair, I.V., Nair, C.M., & Banerjee, M. (2014). DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia. PLoS One, 9(5).
  32. Balan, S., Bharathan, S.P., Vellichiramal, N.N., Sathyan, S., Joseph, V., Radhakrishnan, K., & Banerjee, M. (2014). Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance. PLoS One, 9(2).
  33. Sathyan, S., Koshy, L., Lekshmi, K.S., Easwer, H., Premkumar, S., Alapatt, J.P., Nair, S., Bhattacharya, R., & Banerjee, M. (2013). Lack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a South Indian population. Molecular Biology Reports, 40, 5869–5874.
  34. Balan, S., Sathyan, S., Radha, S.K., Joseph, V., Radhakrishnan, K., & Banerjee, M. (2013). GABRG2 rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures. Pharmacogenetics and Genomics, 23, 605–610.
  35. Chauhan, I., Beena, V., Srinivas, L., Sathyan, S., & Banerjee, M. (2013). Association of cytokine gene polymorphisms with oral lichen planus in Malayalam-speaking ethnicity from South India (Kerala). Journal of Interferon & Cytokine Research, 33, 420–427.
  36. Balan, S., Radha, S.K., Sathyan, S., Vijai, J., Banerjee, M., & Radhakrishnan, K. (2013). Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. Gene, 526, 449–453.