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Arun Kumar G

Assistant Professor

  9961034148

  arunsrnd@gmail.com

Qualifications :  

  • Drug design and development
  • computational and structural biology
  • Biophysical chemistry
  • Bioinformatics
  • Drug repurposing.
  • Design and development of potent drug leads against infectious/ metabolic diseases by using techniques associated with computational and structural biology tools.
  1. KSCSTE-Research fellow, School of life science, Dr. Janaki Ammal campus, Kannur university - (2014 June- 2018 December)
  2. ICMR-SRF, School of life science, Dr. Janaki Ammal campus, Kannur university (2019 January – 2021 December )
  3. JRF, Inter University Center for Biosciences, Dr. Janaki Ammal campus, Kannur university ( 2022 January- June 2022)
  4. Post-Doctoral Fellow, School of Biology, IISER, Thiruvanthapuram. (February 2023- June 2023)
  1. K.G Arun, Sharanya C.S, Abhithaj J, Dileep Francis, Sadasivan C. 2020. Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target. Journal of Biomolecular Structure and Dynamics . Volume 39, Issue 13;4647-4658.
  2. K.G Arun, Sharanya C.S, Abhithaj J, Sadasivan C. 2020. Repurposing of Streptomyces antibiotics as adenosine deaminase inhibitors by pharmacophore modeling, docking, molecular dynamics, and in vitro studies.. Journal of Receptors and Signal Transduction, 40(1):77-88
  3. K.G. Arun, C. Sharanya; J. Abhithaj; C. 2020. In silico and in vitro validation of some benzimidazole derivatives as adenosine deaminase inhibitors. Sadasivan. Indian Journal of Chemistry -Section B (IJC- B),59 (8), 1175-1182
  4. K.G Arun, Sharanya C.S, Abhithaj J, Sadasivan C. 2019. Biochemical and computational insights of adenosine deaminase inhibition by Epigallocatechin gallate, Computational Biology and Chemistry 83,107111.
  5. K. G. Arun, C. S. Sharanya & C. Sadasivan . 2018. Computational and experimental validation of morin as adenosine deaminase inhibitor. Journal of Receptors and Signal Transduction, 38(3):240-245.
  6. K.G. Arun, C.S. Sharanya, P.M. Sandeep, C. Sadasivan. 2016. Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study, Computational Biology and Chemistry 64, 353–358.
  7. J. Abhithaj, C. S. Sharanya, K. G. Arun, E. Jayadevi Variyar & C. Sadasivan (2023) Trypsin is inhibited by phytocompounds liquiritin and terpinen-4-ol from the herb Glycyrrhiza glabra: in vitro and in silico studies, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080 /07391102.2023.2212784.
  8. Sharanya, C., Abhithaj, J., Arun, K. G., Koti Reddy Eeda, Vignesh Bhat, E.J. Variyar, A. Sabu & M.Haridas. Lipoxygenase inhibitory synthetic derivatives of methyl gallate regulate gene expressions of COX-2 and cytokines to reduce animal model arthritis. Sci Rep 13, 10644 (2023).
  9. Bhushanarao Dogga, Eeda Koti Reddy, C.S. Sharanya, J. Abhithaj, K.G. Arun ,C.S. Ananda Kumar, K.S. Rangappa. Design, synthesis and SAR studies of novel tacrine derivatives as potent cholinesterase inhibitors. European Journal of Medicinal Chemistry Reports, 2022, Volume 6, 100094.
  10. Sneha Manthattil Vysyan, Arun Kumar Gangadharan, Sujina Kappadan and Sadasivan Chittalakkottu. 2022. Anti-mycobacterial compound from an endangered medicinal plant Curcuma aeruginosa and identification of its probable targets using in silico method. International Journal of Computational Biology and Drug Design. Vol. 14, No. 6. pp 481-509.
  11. GanjooMahalaxmi, Sivasailam Ashok, Gangadharan Arun, GopalaSrinivas. 2022. Albumin binds to uncoupler CCCP to diminish depolarization of mitochondria. Toxicology in Vitro, Volume 80, 105325.
  12. Dileep Francis , Arun Kumar , Sadasivan Chittalakkottu. 2021. Identification of CD4+ T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking.BioTechnologia. 102(1):43-54.
  13. S Prasnth, G kumar Arun, Madathilkovilakathu Haridas, A. Sabu. 2020. Phycocyanin of marine Oscillatoria sp. inhibits lipoxygenase by protein-protein interaction-induced change of active site entry apace: A model for non-specific biofunctions of phycocyanins. International Journal of Biological Macromolecules, Volume 165, Part A, Pages 1111-1118.
  14. Abhithaj J, Dileep Francis, Sharanya C.S., Arun K.G., Sadasivan C. & E. Jayadevi Variyar 2020. Repurposing Simeprevir, Calpain Inhibitor IV and a Cathepsin F Inhibitor Against SARS-CoV-2: A Study Using in Silico Pharmacophore Modeling and Docking Methods. 2020. Journal of Biomolecular Structure and Dynamics,
  15. C.S. Sharanya, K.G. Arun, A. Sabu, M. Haridas. 2020. Aloe emodin shows high affinity to active site and low affinity to two other sites to result consummately reduced inhibition of lipoxygenase.Prostaglandins and Other Lipid Mediators 150, 106453
  16. J. Abhithaj, K. G. Arun, C. S. Sharanya, M. Haridas & E. Jayadevi Variyar. 2019. Isozymes inhibited by active site blocking: versatility of calcium indifferent Hesperidin binding to phospholipase A2 and its significance. Journal of Receptors and Signal transduction. 39(1):60-66.
  17. Sharanya C. S., Arun K. G., Vijaytha V., Sabu A. & Haridas. 2018. Designing of enzyme inhibitors based on active site specificity: lessons from methyl gallate and its lipoxygenase inhibitory profile. M. Journal of Receptors and Signal Transduction, 2018 Jun;38(3):256-265.
  18. Lakshmanan M. Divyaa, Ganesh K. Prasanth, Kumar G. Arun, C. Sadasivan . 2018. Bisphenol-A carbonate dimer is a more preferred substrate for laccase mediated degradation than the Biphenol-A in its monomeric and dimeric forms.. International Biodeterioration & Biodegradation 135, 19–23.
  19. Abhithaj J, Arun KG, Punya P, Shabeer Ali H, Prasanth S, E Jayadevi Variyar, and M Haridas. 2018. Anti Inflammatory Activity of Ayurvedic Oil, Pinda Tailam is contributed by Trypsin Inhibition. JSM Enzymology and Protein Science. 3(1): 1010.
  20. D. Naveen Chandra; C. Sharanya Suresh; G. Arun Kumar; P.M. Sandeep; A. Sabu; M. Haridas. 2017. Implication of biotransformation of berberine and its derivatives on FtsZ protein: an in silico study.International Journal of Computational Biology and Drug Design Vol. 10, No. 1, pp. 1 – 11.
  21. D. S. Preethidan, G. Arun, M. Prathyusha Surendran, S. Prasanth, A. Sabu, C. Sadasivan and M.Haridas, 2013. Lipoxygenase inhibitory activity of some Sida species due to di(2-ethylhexyl) phthalate,Current Science, Vol. 105, No. 2, pp. 232-237.